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5-Amino-1MQ 5-Amino-1-Methylquinolinium
5-Amino-1MQ is a small-molecule compound and a potent, selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is widely studied for its ability to increase NAD+ levels and promote metabolic health.
Key Characteristics:
Mechanism: Selectively inhibits NNMT, the enzyme responsible for methylating nicotinamide (a precursor to NAD+). By blocking NNMT, it prevents nicotinamide degradation and boosts intracellular NAD+ concentrations.
Action: Enhances sirtuin activity, improves mitochondrial function, and increases energy expenditure.
Properties: Orally bioavailable, stable, and does not significantly affect other methyltransferases.
Research Applications:
Obesity and body composition studies
Metabolic syndrome and insulin resistance research
Age-related metabolic decline and longevity investigations
Mitochondrial biogenesis and NAD+ restoration models
Muscle preservation during weight loss
Non-alcoholic fatty liver disease (NAFLD) and lipid metabolism research
5-Amino-1MQ has gained significant attention in metabolic research as a chemical tool that mimics some benefits of exercise and calorie restriction by elevating NAD+ levels and improving metabolic efficiency. It is often studied for its potential to reduce fat mass while preserving lean muscle.
For laboratory research use only. Not intended for human or veterinary use.
5-Amino-1MQ 5-Amino-1-Methylquinolinium
5-Amino-1MQ is a small-molecule compound and a potent, selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is widely studied for its ability to increase NAD+ levels and promote metabolic health.
Key Characteristics:
Mechanism: Selectively inhibits NNMT, the enzyme responsible for methylating nicotinamide (a precursor to NAD+). By blocking NNMT, it prevents nicotinamide degradation and boosts intracellular NAD+ concentrations.
Action: Enhances sirtuin activity, improves mitochondrial function, and increases energy expenditure.
Properties: Orally bioavailable, stable, and does not significantly affect other methyltransferases.
Research Applications:
Obesity and body composition studies
Metabolic syndrome and insulin resistance research
Age-related metabolic decline and longevity investigations
Mitochondrial biogenesis and NAD+ restoration models
Muscle preservation during weight loss
Non-alcoholic fatty liver disease (NAFLD) and lipid metabolism research
5-Amino-1MQ has gained significant attention in metabolic research as a chemical tool that mimics some benefits of exercise and calorie restriction by elevating NAD+ levels and improving metabolic efficiency. It is often studied for its potential to reduce fat mass while preserving lean muscle.
For laboratory research use only. Not intended for human or veterinary use.
