IGF-1 Des Pre-mixed Pen 2mg

IGF-1 Des Insulin-like Growth Factor-1 Des (1-3)

IGF-1 Des is a truncated, highly potent analog of Insulin-like Growth Factor-1. It lacks the first three amino acids (Gly-Pro-Glu) at the N-terminus, resulting in significantly reduced binding affinity to IGF-binding proteins (IGFBPs) and markedly increased biological activity compared to both native IGF-1 and IGF-1 LR3.

Key Characteristics:

• Structure: Des(1-3) IGF-1 – truncated form missing the N-terminal tripeptide

• Potency: 2–10 times more potent than standard IGF-1 in many tissue types

• IGFBP Affinity: Dramatically lower binding to IGF-binding proteins, allowing higher free IGF-1 levels at the cellular level

• Receptor Interaction: Strong agonist at the IGF-1 receptor

Research Applications:

• Muscle cell proliferation and differentiation (hyperplasia + hypertrophy)

• Enhanced protein synthesis and anabolic signaling

• Accelerated recovery and tissue repair

• Neuroprotection and brain-derived growth factor studies

• Metabolic regulation and fat utilization research

• Studies on localized growth factor effects

Due to its high potency and reduced IGFBP binding, IGF-1 Des is frequently used in laboratory research exploring maximal anabolic and regenerative responses, particularly in muscle and neural tissue models.

For laboratory research use only. Not for human or veterinary use.