Kisspeptin pre mixed pen 10/5mg

Kisspeptin-10 / Metastin

Kisspeptin is a neuropeptide that plays a central role in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis. It is the endogenous ligand for the G-protein-coupled receptor KISS1R (formerly GPR54).

Key Characteristics:

• Sequence (Kisspeptin-10): Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

• Mechanism: Potent stimulator of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus, leading to increased secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)

• Properties: Acts as the master regulator (“gatekeeper”) of puberty onset and reproductive function

• Potency: Extremely high – nanomolar concentrations are biologically active

Research Applications:

• Reproductive endocrinology and fertility studies

• Regulation of puberty onset and hypothalamic amenorrhea research

• Polycystic ovary syndrome (PCOS) and hypogonadotropic hypogonadism models

• Gonadotropin pulse generator investigations

• Neuroendocrine control of reproduction and sex hormone feedback loops

• Potential therapeutic modulation of the HPG axis

Kisspeptin is widely regarded as one of the most important discoveries in reproductive neuroendocrinology. It is frequently used in laboratory research to study the upstream control of GnRH pulsatility and its downstream effects on LH/FSH release and gonadal function.

For laboratory research use only. Not intended for human or veterinary use.