MOTS C Pre-mixed Pen 40mg

MOTS-c Mitochondrial Open Reading Frame of the 12S rRNA-c

MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by the 12S rRNA region of the mitochondrial genome. It functions as a bioactive signaling molecule that regulates metabolism at both the cellular and systemic levels.

Key Characteristics:

• Sequence: MRWQEMGYIFYPRKLR

• Origin: Translated from a short open reading frame within the mitochondrial 12S rRNA

• Mechanism: Translocates to the nucleus under metabolic stress and regulates gene expression related to metabolism; activates AMPK, enhances insulin sensitivity, and modulates fatty acid metabolism

• Properties: Exercise-mimetic effects; improves metabolic flexibility and mitochondrial function

Research Applications:

• Metabolic syndrome and type 2 diabetes research

• Insulin sensitivity and glucose homeostasis studies

• Obesity and body composition investigations

• Mitochondrial function and bioenergetics

• Age-related metabolic decline and longevity studies

• Exercise physiology and muscle metabolism models

• Inflammation and oxidative stress research

MOTS-c is one of the most studied mitochondrial-derived peptides due to its powerful ability to improve metabolic health, enhance insulin sensitivity, and mimic some beneficial effects of exercise. It represents a novel class of mitochondria-to-nucleus retrograde signaling molecules.

For laboratory research use only. Not intended for human or veterinary use.