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PT-141 Bremelanotide
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). Unlike traditional PDE5 inhibitors, it acts centrally in the brain to modulate sexual arousal and desire.
Key Characteristics:
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Mechanism: Selective agonist of the melanocortin-4 receptor (MC4R) in the hypothalamus and limbic system
Action: Stimulates sexual arousal pathways independent of vascular mechanisms
Half-life: Approximately 2–3 hours
Research Applications:
Sexual dysfunction and hypoactive sexual desire disorder (HSDD) studies
Central modulation of sexual motivation and behavior
Erectile dysfunction and arousal disorder research (both male and female)
Melanocortin receptor pathway investigations
Neuroendocrine regulation of libido and reward systems
PT-141 is notable in laboratory research for its unique central mechanism of action, distinguishing it from peripherally acting compounds. It is frequently studied for its potential to enhance sexual desire and arousal through direct neurological pathways.
For laboratory research use only. Not intended for human or veterinary use.
PT-141 Bremelanotide
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). Unlike traditional PDE5 inhibitors, it acts centrally in the brain to modulate sexual arousal and desire.
Key Characteristics:
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Mechanism: Selective agonist of the melanocortin-4 receptor (MC4R) in the hypothalamus and limbic system
Action: Stimulates sexual arousal pathways independent of vascular mechanisms
Half-life: Approximately 2–3 hours
Research Applications:
Sexual dysfunction and hypoactive sexual desire disorder (HSDD) studies
Central modulation of sexual motivation and behavior
Erectile dysfunction and arousal disorder research (both male and female)
Melanocortin receptor pathway investigations
Neuroendocrine regulation of libido and reward systems
PT-141 is notable in laboratory research for its unique central mechanism of action, distinguishing it from peripherally acting compounds. It is frequently studied for its potential to enhance sexual desire and arousal through direct neurological pathways.
For laboratory research use only. Not intended for human or veterinary use.
