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SLU-PP-332 Pan-Estrogen-Related Receptor (ERR) Agonist
SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ), with highest potency at ERRα. It functions as a chemical “exercise mimetic” by activating transcriptional programs normally induced by aerobic exercise.
Key Characteristics:
Mechanism: Binds to the ligand-binding domain of ERRs, recruiting coactivators such as PGC-1α, leading to upregulation of genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation
Potency: EC₅₀ ≈ 98 nM at ERRα (most potent), with activity across all three ERR isoforms
Action: Induces an acute aerobic exercise-like transcriptional response in skeletal muscle, increasing energy expenditure, mitochondrial function, and oxidative fiber capacity without requiring physical activity
Research Applications:
Metabolic syndrome and obesity models
Exercise mimetic and endurance enhancement studies
Mitochondrial biogenesis and bioenergetics research
Fatty acid oxidation and body composition investigations
Heart failure and cardiac metabolic remodeling
Age-related metabolic decline and sarcopenia studies
Type 2 diabetes and insulin sensitivity research
SLU-PP-332 is one of the first well-characterized pan-ERR agonists shown to replicate key metabolic benefits of exercise, including reduced fat mass, improved insulin sensitivity, and enhanced exercise capacity in preclinical models. It is a valuable tool for studying ERR-mediated metabolic regulation and potential therapeutics for metabolic diseases.
For laboratory research use only. Not intended for human or veterinary use.
SLU-PP-332 Pan-Estrogen-Related Receptor (ERR) Agonist
SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ), with highest potency at ERRα. It functions as a chemical “exercise mimetic” by activating transcriptional programs normally induced by aerobic exercise.
Key Characteristics:
Mechanism: Binds to the ligand-binding domain of ERRs, recruiting coactivators such as PGC-1α, leading to upregulation of genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation
Potency: EC₅₀ ≈ 98 nM at ERRα (most potent), with activity across all three ERR isoforms
Action: Induces an acute aerobic exercise-like transcriptional response in skeletal muscle, increasing energy expenditure, mitochondrial function, and oxidative fiber capacity without requiring physical activity
Research Applications:
Metabolic syndrome and obesity models
Exercise mimetic and endurance enhancement studies
Mitochondrial biogenesis and bioenergetics research
Fatty acid oxidation and body composition investigations
Heart failure and cardiac metabolic remodeling
Age-related metabolic decline and sarcopenia studies
Type 2 diabetes and insulin sensitivity research
SLU-PP-332 is one of the first well-characterized pan-ERR agonists shown to replicate key metabolic benefits of exercise, including reduced fat mass, improved insulin sensitivity, and enhanced exercise capacity in preclinical models. It is a valuable tool for studying ERR-mediated metabolic regulation and potential therapeutics for metabolic diseases.
For laboratory research use only. Not intended for human or veterinary use.
