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SS-31 Elamipretide / Szeto-Schiller Peptide 31
SS-31 (Elamipretide) is a synthetic tetrapeptide specifically designed to target the inner mitochondrial membrane. It belongs to the Szeto-Schiller (SS) class of cell-permeable, mitochondria-targeting peptides.
Key Characteristics:
Sequence: D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH₂
Mechanism: Selectively binds to cardiolipin in the inner mitochondrial membrane, reducing electron leakage, inhibiting cytochrome c peroxidase activity, and optimizing electron transport chain efficiency
Properties: Potent antioxidant and mitochondrial protective effects; penetrates cell membranes and accumulates in mitochondria in a membrane potential-independent manner
Action: Decreases reactive oxygen species (ROS) production while preserving ATP synthesis
Research Applications:
Mitochondrial dysfunction and bioenergetics studies
Ischemia-reperfusion injury and organ protection research
Neurodegenerative diseases (Alzheimer’s, Parkinson’s, ALS)
Heart failure and cardiac muscle protection models
Age-related mitochondrial decline and sarcopenia
Kidney disease and acute kidney injury studies
Oxidative stress-related inflammatory conditions
SS-31 is one of the most advanced mitochondria-targeted peptides in research. It is highly valued for its ability to improve mitochondrial function and reduce oxidative damage without interfering with normal cellular signaling.
For laboratory research use only. Not intended for human or veterinary use.
SS-31 Elamipretide / Szeto-Schiller Peptide 31
SS-31 (Elamipretide) is a synthetic tetrapeptide specifically designed to target the inner mitochondrial membrane. It belongs to the Szeto-Schiller (SS) class of cell-permeable, mitochondria-targeting peptides.
Key Characteristics:
Sequence: D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH₂
Mechanism: Selectively binds to cardiolipin in the inner mitochondrial membrane, reducing electron leakage, inhibiting cytochrome c peroxidase activity, and optimizing electron transport chain efficiency
Properties: Potent antioxidant and mitochondrial protective effects; penetrates cell membranes and accumulates in mitochondria in a membrane potential-independent manner
Action: Decreases reactive oxygen species (ROS) production while preserving ATP synthesis
Research Applications:
Mitochondrial dysfunction and bioenergetics studies
Ischemia-reperfusion injury and organ protection research
Neurodegenerative diseases (Alzheimer’s, Parkinson’s, ALS)
Heart failure and cardiac muscle protection models
Age-related mitochondrial decline and sarcopenia
Kidney disease and acute kidney injury studies
Oxidative stress-related inflammatory conditions
SS-31 is one of the most advanced mitochondria-targeted peptides in research. It is highly valued for its ability to improve mitochondrial function and reduce oxidative damage without interfering with normal cellular signaling.
For laboratory research use only. Not intended for human or veterinary use.
