VIP Pre-mixed Pen 5mg

VIP Vasoactive Intestinal Peptide

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the secretin/glucagon family. It functions as both a neurotransmitter and a hormone with wide-ranging physiological effects, particularly in the gastrointestinal, respiratory, and immune systems.

Key Characteristics:

• Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂

• Mechanism: Acts primarily through VPAC1 and VPAC2 receptors (G-protein coupled receptors), increasing intracellular cAMP levels

• Properties: Potent vasodilator, anti-inflammatory, immunomodulatory, and neuroprotective effects

• Half-life: Very short (~2–5 minutes) in circulation

Research Applications:

• Anti-inflammatory and immunomodulatory studies

• Inflammatory bowel disease (IBD) and gut motility research

• Pulmonary hypertension and asthma models

• Neuroprotection and neurodegenerative disease investigations

• Autoimmune disorders and cytokine storm modulation

• Smooth muscle relaxation and vasodilation research

VIP is widely studied for its broad therapeutic potential due to its ability to regulate immune responses, reduce inflammation, and promote tissue protection without significant toxicity. It is particularly noted for its role in balancing pro- and anti-inflammatory pathways.

For laboratory research use only. Not intended for human or veterinary use.